venlafaxine attenuates heat hyperalgesia independent of adenosine or opioid system in a rat model of peripheral neuropathy

نویسندگان

alireza abed department of pharmacology and toxicology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

valiollah hajhashemi department of pharmacology and toxicology and pharmaceutical research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

hamid reza banafshe department of addiction studies, school of medicine, kashan university of medical sciences, kashan. iran.

mohsen minaiyan 1department of pharmacology and toxicology and pharmaceutical research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

چکیده

primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. this study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. we have evaluated the effect of caffeine, a non-selective adenosine a1 and a2 receptor antagonist and naloxone as an antagonist of opioid receptors on the antinociceptive effects of venlafaxine. chronic constriction injury of the sciatic nerve resulted in thermal hyperalgesia, mechanical and cold allodynia in the rats. animals were received on the 7th day after surgery, when the model had been fully established, venlafaxine (20 and 40 mg/kg i.p.), or venlafaxine (40 mg/kg) in combination with caffeine (5 mg/kg i.p.) or naloxone (1 mg/kg s.c.). rats were tested for thermal reaction latencies, mechanical and cold allodynia 45 min after drug injection. acute venlafaxine (40 mg/kg i.p.) administration consistently decreased the thermal hyperalgesia and this effect was not blocked by concomitant caffeine or naloxone administration. there was no effect by either drug or the drug combination on the tactile and cold allodynia. the results of this study indicate that venlafaxine (40 mg/kg i.p.) is effective in alleviating thermal hyperalgesia and this effect is independent through manipulation of adenosine or opioid system. this observation demonstrates that venlafaxine, which is a mixed inhibitor of norepinephrine and serotonin reuptake, differs from the other antidepressants in the mechanism of its antinociception action.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

متن کامل

Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

متن کامل

Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

متن کامل

Microinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model

Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and ho...

متن کامل

Antinociceptive effects of maprotiline in a rat model of peripheral neuropathic pain: possible involvement of opioid system

Objective(s): Neuropathic pain remains a clinical problem and is poorly relieved by conventional analgesics. This study was designed to determine whether maprotiline administration was effective in alleviating symptoms of neuropathic pain and whether the antinociceptive effect of maprotiline mediated through the opioid system. Materials and Methods: Neuropathic pain was induced by chronic cons...

متن کامل

Role of opioid system in verapamil-induced antinociception in a rat model of orofacial pain

Calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. In the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. Orofacial pain was induced by subcutaneous (SC) injection of for...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۴، شماره ۳، صفحات ۸۴۳-۸۵۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023